THORNEMethyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports methylation & Healthy Level of homocysteine* - Gluten, Dairy & Soy-Free - 90 Capsules

I see some negative reviews, some of them stating the dosage is just too high. My doctor recommended taking this for my high homocysteine levels, but said to only take one capsule per day, not three. He basically agrees that the manufacturer's recommended dosage of three per day is too high. But I initially started taking two per day anyway, to get more TMG. But then I switched to one per day like my doctor suggested, plus an additional separate 1000 mg TMG.Even one per day might be a high dose if you don't specifically have a requirement. But since I do, one per day has been working well for me. My recent blood homocysteine blood level was improved.If even one per day is too high of a dose for you, you might consider the regular Thorne Methyl-Guard instead of the Plus. Basically, the Thorne products are really good but adjust dose per your personal needs. And like me, you could also add a TMG-only supplement if you want more of that specifically.Other people complain about pill size. I personally don't have a problem with larger pills as long as I swallow them with food. That works for me.Another complaint is the price. It's not cheap. But since I only take one per day, a bottle lasts me 90 days not 30. So that helps with the cost.

Great product. Combination of supplements instead of buying them separately. Would recommend.

Repeat order of this supplement. Very good quality and bottle was sealed well. Will continue to order.

THORNE Methyl-Guard Plus was recommended by two doctors for my methylation issues. I specifically search for methylated B vitamins and avoid synthetics. Unfortunately, I have malabsorption issues so I am not sure how well this product worked. My vitamin B levels have increased dramatically so I had to stop taking. I also feel this product is a bit spendy for a one month supply. I would only take 1 capsule a day to try and stretch it out. I do find Thorne products to be of best quality.

I'm a big believer in investing in high-quality supplements, and Thorne Research is one of the brands I trust most. Their Methyl-Guard Plus is a great option for anyone looking to support their methylation pathways, especially if they have the MTHFR gene mutation.I've been using Methyl-Guard Plus for a few months now, and I've noticed a significant improvement in my energy levels and overall well-being. I also appreciate that it doesn't cause any stomach upset, which is a common problem with other B-vitamin supplements.If you're looking for a high-quality, effective B-vitamin supplement, I highly recommend Thorne Research's Methyl-Guard Plus.

I, like most people, am sensitive to large doses of the vitamins—- so —-I open the capsule and sprinkle a little bit in my mouth… Perhaps a sixth of the capsule.I also take it alongside 1/4 to 1 mg of lithium orotate.Those two things really improve my mood.Lithium is definitely something to be careful with, but I’ve read that high doses of B12 can deplete lithium.I do run into that if I take this supplement without it for too many days in a row. I get agitated.

This vitamin has helped me so much with my energy levels. My naturopath told me to get it. This is a very good and trustworthy brand.

I starting taking this after getting some (SpectraCell) testing done that said I was deficient in the various B vitamins and I had the MTHFR genetic defect that prevents methylation. I felt like crap for the last decade and my usual doctors weren't of any help. I eat very healthy and eat very well too as I thought that would make me better. I won't go into details but I always knew something was wrong and nothing else worked. Anyway, so i read about methyl folate and methylation, MTHFR etc. and I get this to start to "fix"it. Immediately I felt FAR worse than I ever did before. Headaches, brain fog, extreme fatigue. So I stopped taking it and I go back to the sites and learn this is normal reaction. So then I read you should boost your other B vitamins first without the methyl folate or b12 and then add this back in. So I did with a product called B Minus for about 2 months then I added this product back in. Now 2 months in to taking this I feel like I'm finally waking up and getting more energy and I feel fantastic. No side effects. And a lot of my old symptoms are gone or fading away. I held off writing a review b/c I've been so disappointed after taking so many supplements over the years but this one seems to be actually working. It can take 6 -12 months to see full results and get your levels back to where they should be so I can't imagine how I'll feel by then. I'm going to retest through Spectracell in 6 months and see where my levels are at. If you're not familiar with Spectracell, look into it. Most regular doctors won't have it and it's not covered under insurance. I actually went to a nutritionist to get it done. It's the best decision I've ever made for my health. I'm just sad that it took me so long to find the answers. Good luck to you.