---
product_id: 49917744
title: "E45 Itch Relief Cream 500g – Treatment for Eczema, Dry Skin, Dermatitis and Itchy Skin – Instant 24-Hour Hydration with Urea for Moisture Retention - Perfume free and dermatologically tested"
brand: "e45"
price: "€ 45.70"
currency: EUR
in_stock: true
reviews_count: 13
category: "E45"
url: https://www.desertcart.ie/products/49917744-e45-itch-relief-cream-500g-treatment-for-eczema-dry-skin
store_origin: IE
region: Ireland
---

# 5% Urea for deep hydration 24-hour itch relief 500g pump for easy, mess-free use E45 Itch Relief Cream 500g – Treatment for Eczema, Dry Skin, Dermatitis and Itchy Skin – Instant 24-Hour Hydration with Urea for Moisture Retention - Perfume free and dermatologically tested

**Brand:** e45
**Price:** € 45.70
**Availability:** ✅ In Stock

## Summary

> 💧 Stay itch-free, hydrated, and confident all day long!

## Quick Answers

- **What is this?** E45 Itch Relief Cream 500g – Treatment for Eczema, Dry Skin, Dermatitis and Itchy Skin – Instant 24-Hour Hydration with Urea for Moisture Retention - Perfume free and dermatologically tested by e45
- **How much does it cost?** € 45.70 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.ie](https://www.desertcart.ie/products/49917744-e45-itch-relief-cream-500g-treatment-for-eczema-dry-skin)

## Best For

- e45 enthusiasts

## Why This Product

- Trusted e45 brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Long-Lasting Hydration:** Urea-enriched formula locks in moisture for a full 24 hours of skin comfort.
- • **Generous 500g Pump Bottle:** Convenient, hygienic dispensing that fits your busy lifestyle and keeps skin care effortless.
- • **Trusted Legacy Since 1952:** Decades of proven expertise in dry and itchy skin care, making it a must-have in your wellness routine.
- • **Dual-Action Soothing Power:** Targets itching & irritation from eczema, dermatitis, and dry skin for instant calm.
- • **Dermatologist-Approved & Perfume-Free:** Gentle enough for sensitive skin, infants 1 month+, and daily use without irritation.

## Overview

E45 Itch Relief Cream is a dermatologist-tested, perfume-free treatment designed to soothe itching and irritation caused by eczema, dermatitis, and dry skin. Featuring 5% urea for intense moisture retention and lauromacrogols for anti-itch relief, this non-greasy cream provides instant comfort and 24-hour hydration. Packaged in a convenient 500g pump bottle, it’s suitable for adults and infants over 1 month, backed by over 60 years of trusted skincare expertise.

## Description

Product Description E45 Itch Relief Cream contains an anti-itch ingredient, lauromacrogols, which treats and soothes the itching caused by eczema, dermatitis, pruritus and scaling skin conditions. Formulated with urea, a moisturiser found naturally within the skin, E45 Itch Relief Cream is non-greasy, moisturising and can soothe the skin and leave it feeling calm and comfortable. RB-M-01759. Ingredients Dimeticone, Phenyl Dimeticone, Liquid Paraffin, Cetyl Palmitate, Stearic Palmitic Acid, Octyldodecanol, Glycerol, Polysorbate, Carbomer, Trometamol, Benzyl Alcohol, Purified Water. P.when('A').execute(function(A) { A.on('a:expander:toggle_description:toggle:collapse', function(data) { window.scroll(0, data.expander.$expander[0].offsetTop-100); }); }); Directions Twist pump to open position, depress pump to dispense cream, twist back to lock, apply to the affected skin 2 times daily, if symptoms persist, consult your doctor, each use of the pump dispenses approx 4 g of cream, E45 Itch Relief Cream for pruritus, eczema, dermatitis, and scaling skin conditions, always read the label Box Contains 1 X E45 Itch Relief Cream - 500 g See more

Review: Life saver - This is a life saver I have very itchy upper arms since my stroke non greasy & pump easy to use I’d recommend it every time
Review: Nice and smooth - Very happy, it can also be used as a general moisturiser, its smooth and "creamy" (Wouldn't want to eat it though) it is absorbed quickly into the skin

## Features

- TREAT ITCHING AND SKIN IRRITATION – E45 Itch Relief Cream is a dual action treatment for skin irritation and itching caused by dry skin conditions, eczema, dermatitis, pruritus, and scaling skin conditions
- MOISTURISING AND ANTI-ITCH INGREDIENTS – E45 Itch Relief Cream is formulated with urea which helps your skin to retain moisturise and keeps it hydrated. Our cream is also dermatologically tested to provide effective relief for itchy skin
- HOW TO USE – Apply to the affected skin area twice daily for effective relief for itching and skin irritation. Our cream is perfume free and can be used in all skin areas, body, face, and hands. Suitable for adults and infants over the age of 1 month
- QUALITY SKINCARE EVERY DAY – For 60 years, E45 has been a skincare expert in dry and itchy skin and treatment for eczema, psoriasis, ichthyosis and other dry skin conditions. It has proven dermatological expertise dedicated to vulnerable dry skin
- HISTORY OF E45 – We released our E45 Cream in 1952 after a customer request for a product that would soothe and protect the skin. In 1963 our cream was introduced to pharmacy and retail in 1980

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B001EJOHUU |
| ASIN  | B001EJOHUU |
| Additives | Lauromacrogols 3.0%w/w, Urea 5.0%w/w |
| Age Range Description | Adult |
| Best Sellers Rank | 942 in Health & Personal Care ( See Top 100 in Health & Personal Care ) 6 in Itching & Rash Treatments |
| Brand | E45 |
| Customer Reviews | 4.6 4.6 out of 5 stars (3,172) |
| Customer reviews | 4.6 4.6 out of 5 stars (3,172) |
| Date First Available | 6 Aug. 2008 |
| Format | Cream |
| Is discontinued by manufacturer  | No |
| Item model number  | 348713 |
| Manufacturer  | E45 |
| Product Dimensions  | 5 x 5 x 24 cm; 550 g |
| Product Name | E45 Dermatological Itch Relief Cream 500g |
| Units | 500.0 Grams |
| Weight | 500 g |

## Product Details

- **Active ingredients:** urea
- **Age range (description):** Adult
- **Brand:** E45
- **Item dimensions L x W x H:** 50 x 50 x 240 millimetres
- **Item form:** Cream
- **Item volume:** 500 Millilitres
- **Number of items:** 1
- **Scent:** Unscented
- **Skin type:** All
- **Special feature:** Travel Size

## Images

![E45 Itch Relief Cream 500g – Treatment for Eczema, Dry Skin, Dermatitis and Itchy Skin – Instant 24-Hour Hydration with Urea for Moisture Retention - Perfume free and dermatologically tested - Image 1](https://m.media-amazon.com/images/I/51Y6C5624FL.jpg)

## Questions & Answers

**Q: Is this antibacterial?**
A: It does not state anywhere on the container that it is antibacterial.  My mother has very sensitive skin and prone to itching and E45 itch relief cream helps her condition.

**Q: What is the expiry date please**
A: It is about three years or so. The actual expiry date is printed on the label, near the back , within  a small blue printed area about one inch square.
I expect it would last much longer.

**Q: ordered 1 500 gr m itch reamand bill comes  ?!£8; please correct it**
A: THe price in UK is approximately £25 per 500ml

**Q: Is this product good to use for prickly heat rash please**
A: Hi there, Good question; Product should not be used on infected or inflamed skin. However we would suggest speaking to a health care professional and getting their advice to check if E45 Itch Relief Cream would be suitable for your specific needs.[ E45 Itch Relief Cream for pruritus, eczema, dermatitis, and scaling skin conditions. Always read the label.]

## Customer Reviews

### ⭐⭐⭐⭐⭐ Life saver
*by G***A on 1 November 2025*

This is a life saver I have very itchy upper arms since my stroke non greasy & pump easy to use I’d recommend it every time

### ⭐⭐⭐⭐⭐ Nice and smooth
*by B***B on 7 January 2026*

Very happy, it can also be used as a general moisturiser, its smooth and "creamy" (Wouldn't want to eat it though) it is absorbed quickly into the skin

### ⭐⭐⭐⭐⭐ Relieves skin irritation
*by U***4 on 7 December 2025*

Cream is fast absorbent which helps relieve skin irritation. Recommended

## Frequently Bought Together

- E45 Itch Relief Cream 500G
- E45 Wash Cream 250ml
- E45 shower cream 200ml

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*Product available on Desertcart Ireland*
*Store origin: IE*
*Last updated: 2026-02-22*