---
product_id: 4077382
title: "SAMe 400"
brand: "jarrow formulas"
price: "€ 52.77"
currency: EUR
in_stock: null
url: https://www.desertcart.ie/products/4077382-same-400
store_origin: IE
region: Ireland
---

# Vegan & allergen-free formula 400 mg active S,S-SAMe per tablet Enteric-coated for max bioavailability SAMe 400

**Brand:** jarrow formulas
**Price:** € 52.77
**Availability:** ❌ Out of Stock

## Summary

> 💡 Elevate your daily wellness game with the pure power of SAMe!

## Quick Answers

- **What is this?** SAMe 400 by jarrow formulas
- **How much does it cost?** € 52.77 with free shipping
- **Is it available?** Currently out of stock
- **Where can I buy it?** [www.desertcart.ie](https://www.desertcart.ie/products/4077382-same-400)

## Best For

- jarrow formulas enthusiasts

## Why This Product

- Trusted jarrow formulas brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Holistic Health Support:** Clinically backed to boost joint comfort, liver detoxification, brain metabolism, and balanced mood—your all-in-one daily vitality ally.
- • **Clean & Conscious Wellness:** Vegan, gluten-free, and free from 10+ common allergens—perfect for the mindful professional with dietary restrictions.
- • **Cutting-Edge Stability Tech:** Manufactured under low heat and humidity, plus blister-packed to preserve potency and freshness until the last tablet.
- • **Precision-Powered 400 mg Dose:** Each tablet delivers a potent 400 mg of biologically active S,S-SAMe, ensuring you get the premium form your body truly needs.
- • **Shielded for Superior Absorption:** Enteric coating protects SAMe from stomach acid, maximizing absorption and delivering peak benefits where it counts.

## Overview

Jarrow Formulas SAMe 400 mg offers a high-concentration, enteric-coated, vegan-friendly supplement designed to support joint health, liver function, brain metabolism, and mood balance. Each tablet delivers the biologically active S,S form of SAMe, preserved through advanced low-temp manufacturing and blister packaging to ensure maximum potency and absorption. Free from common allergens and suitable for diverse dietary needs, this 30-day supply empowers professionals to maintain holistic wellness with a single daily dose.

## Description

Product Description               Jarrow Formulas SAMe provides SAMe (S-Adenosyl Methionine), a naturally derived compound that plays a role in supporting various biochemical systems in the body. Each tablet of Jarrow Formulas SAMe provides 400 mg of SAMe to provide benefits. Jarrow Formulas SAMe offers a wide array of benefits that can support various aspects of your health and well-being. SAMe supports joint health, and liver function.* Jarrow Formulas SAMe is non-GMO, vegan-friendly, and gluten free, making it an ideal choice for those with dietary restrictions.* These tablets are also wheat free, soy free, dairy free, egg free, fish/shellfish free, peanut/nut free, and sesame free. Taking Jarrow Formulas SAMe is simple and convenient. Adults should take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional. At Jarrow Formulas, we aren't your typical vitamin company. We believe everyone has the right to feel good in their own body. Jarrow Formulas’ original goal has always remained the same: To design superior dietary supplements that help empower individuals to take charge of their own health. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.                  .com               Jarrow Formulas SAM-e 400, 400mg, 30 TabletsAt a Glance:Contributes to the proper functioning of many biochemical systemsIdeal for those wanting to optimize cognitive function, mood, energy levels, liver activity and joint health*Preserved bioavailability through low-temp and low-moisture manufacturingProcessed without solventsProtected from degradation via enteric coating and blister-packaging SAM-e contributes to the proper functioning of many biochemical systems. S-adenosyl-L-methionine (SAM-e) is an amino acid derivative clinically documented to benefit brain, liver and joint function*. View larger. S-adenosyl-L-methionine (SAM-e) is an amino acid derivative clinically documented to benefit brain, liver and joint function.* Found in all living cells, SAM-e is called "activated methionine" and is formed via combination of ATP with methionine. Somewhat counterintuitively, however, methionine supplementation does not elevate SAM-e levels in the body. Rather, it elevates problematic homocysteine. SAM-e has undergone many clinical trials involving thousands of human subjects. Researchers have identified many structure- and function-based benefits of SAM-e involving over 40 biochemical processes. It is a biochemical workhorse with various diverse effects on the body, including improving liver function, supporting joint health and lifting mood.*Liver Detoxification SAM-e metabolism supports glutathione (GSH) synthesis and glutathione-dependent enzymes, which support liver function.* GSH, the chief antioxidant and detoxifier inside cells, scavenges free radicals produced during carbohydrate breakdown for energy. Taurine is another end product of SAM-e metabolism. GSH and taurine are important for liver detoxification.*Brain Function SAM-e supports brain function by its methylation effects.* Methylation is the transfer of a methyl group (one carbon and three hydrogen atoms, CH3) from one molecule to another. SAM-e is the most important of all methyl-donors in mammalian metabolism. Donation of methyl groups supports numerous metabolic processes including brain function, energy production and DNA metabolism. Neurotransmitters, substances involved in nerve cell communication, are also products of methylation. These compounds include L-DOPA, dopamine, serotonin, epinephrine and phosphatidylcholine (in lecithin). SAM-e is thought to benefit cognitive health by supporting the production of such critical brain messengers.* In fact, many people report noticeable positive effects on brain and mood after only taking it for a short time.*Energy Production Methylation from SAM-e is also critical for creatine production. Creatine metabolites are important for ADP to ATP recycling and storing energy for immediate needs. Supporting creatine levels may help maximize physical performance, reduce exercise fatigue and improve recovery after exercise.*Longevity A healthy young body manufactures all the SAM-e it needs. However, with age, people are less able to produce adequate SAM-e. This may contribute to declining health on many levels. Fortunately, these disturbances are often boosted by SAM-e supplementation.* In addition, methylation of DNA is an important part of DNA repair. De-methylation of DNA contributes to the aging process. Proper methylation, via substances such as SAM-e, positively influences longevity.*Healthy Connective Tissue Research has shown that regular SAM-e supplementation helps support joint health, and is used regularly in Europe to promote joint mobility and comfort.*Not All SAM-e is Created Equal SAM-e exists in two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is inactive. Jarrow Formulas SAM-e is predominantly the active form. It is made naturally by microbiological fermentation and then specially processed, without solvents, to preserve 68-80 percent (S,S) SAM-e, the highest active level available. SAM-e is a highly reactive molecule and very fragile. It degrades rapidly under high heat or humidity. Improper handling of SAM-e can cause degradation in a matter of hours. Thus, the manufacturing process for Jarrow Formulas SAM-e is done under low temperature and low humidity, and the tablet is enteric coated and blister-packed. Pharmacokinetic studies show that oral supplementation of SAM-e is most effective when enteric-coated by special gastric fluid-resistant polymers, resulting in maximum blood levels.*Note: Side effects are rare and appear to be limited to gastrointestinal disturbances. This product complies with the proposed USP Monograph for SAM-e.Warning: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e.About Jarrow Formulas Jarrow Formulas' complete line of over 350 nutritional products includes vitamins, minerals, probiotics, standardized herbal concentrates, amino acids, enzymes and enteral nutrition products. Customers can be assured of purity, value and potency when choosing these products.What's in the Box Jarrow Formulas SAM-e 400, 400mg, 30 Tablets.Other Products from Jarrow Formulas:

## Features

- One (1) bottle of Jarrow Formulas SAMe 400 mg Extra Strength Vegan Naturally Derived SAMe Dietary Supplement, SAMe Supplement Supports Joint Health, Liver Health and Brain Health, for a 30-day supply
- SAMe balanced mood support supplement formula provides 400 mg SAMe from 800 mg of SAMe tosylate disulfate and is enteric-coated to ensure a biologically active product
- SAMe supports brain metabolism and the production of healthy connective tissue for joint support; SAMe metabolism supports glutathione synthesis for antioxidant and liver support
- These brain supplements for memory are vegan, wheat free, gluten free, soy free, dairy free, egg free, fish free, shellfish free, peanut free, tree nut free and sesame free for an allergy friendly supplement
- Suggested Use for SAMe supplement: Adults take 1 tablet a day on an empty stomach or as directed by your qualified healthcare professional

## Product Details

- **Brand:** Jarrow Formulas
- **Flavor:** Unflavored
- **Primary Supplement Type:** Vitamin
- **Unit Count:** 30.0 Count
- **Item Form:** Tablet
- **Item Weight:** 0.13 Pounds
- **Item dimensions L x W x H:** 2 x 3 x 5 inches
- **Special Ingredients:** Amino Acid, Lecithin
- **Diet Type:** Vegetarian
- **Product Benefits:** Brain Health Support

## Images

![SAMe 400 - Image 1](https://m.media-amazon.com/images/I/712gkRyqlDL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: Does this one hace mannitol in it?**
A: I don't know why this has mannitol, but I suspect many who have GI reactions to this supplement are actually reacting to the mannitol, as it can be used as a laxative.  I would test myself with a mild mannitol prep before buying a supplement containing mannitol, as you may have to discard an expensive supplement.

**Q: Does anyone make a brand with no Mannitol and no Titanium dioxide with a butanedisulfonate form in enteric-coated tablets?**
A: Yep, Azendus does and for a while now they've been the only company in the U.S. that has the patent to make the butanedisulfonate version after GNC's expired. Butanedisulfonate is the formula used in SAM-e clinical studies for treating depression.

**Q: Other ingredients?  Most supplements contain a lot of other ingredients besides the SAM-3 which I do NOT want to be exposed to.  Ingredients, please?**
A: Other Ingredients: Cellulose, silicon dioxide, glyceryl behenate, magnesium stearate (vegetable source), enteric coating (methacrylate copolymers), titanium dioxide, magnesium silicate, triethylcitrate, riboflavin, glycerol palmitostearate, medium chain triglycerides, carboxymethyl starch sodium salt and mannitol.Suitable for vegetarians/vegans.

**Q: How come a month later I feel no effect whatsoever with any of the benefits it provides?**
A: We recommend to discuss your health goals with your doctor and proceed with their guidance. Establishing the most effective dose may require trial and error, along with supervision, depending on your specific goals.

## Frequently Bought Together

- Jarrow Formulas SAMe 400 mg, Supports Joint Health, Liver Function, Brain Metabolism, 30 Tablets, Up To a 30 Day Supply
- Jarrow Formulas Magnesium L-Threonate, MagMind Magtein Brain Supplements for Memory Support, 90 Veggie Capsules, Up to a 30 Day Supply
- Jarrow Formulas® SAMe 200 mg, Supports Joint Health, Liver Function, Brain Metabolism, 60 Tablets, Up To A 60 Day Supply

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*Product available on Desertcart Ireland*
*Store origin: IE*
*Last updated: 2026-02-24*