Optimized Folate (L-Methylfolate) 1700 mcg DFE, 180 Veg Tablets

I switched from 10X due to availability a few months ago and am really satisfied.

I read about this product in The Keto Cure. I had a dear friend die from the JC virus, which eats the brain. One of the things the doctor put him on was pharmaceutical grade l-methylfolate to accentuate his remaining mental function. The JC virus is always fatal so, whether it worked or not, only God knows. I always appreciate when MDs trust a supplement enough to prescribe it. There must be reasons. With me, it helped me burst through a Keto diet slowdown. I believe it makes me more mentally alert. After taking this and admittedly many other supplements, I got my blood tests done. PERFECT, all the way down the chart. And that at 40 pounds overweight. It's reasonable to believe this "works".

The little known (but crucial) difference between folate and folic acid. If I asked you which of these vitamins was found naturally in food, folate or folic acid, would you know the answer? If not, you’re in good company. Many health professionals would even argue that folate and folic acid are essentially the same nutrient. While folic acid is often considered to be a supplemental form of folate, there is an important distinction between these two different compounds. What’s the difference between folate and folic acid? Folate is a general term for a group of water soluble b-vitamins, and is also known as B9. Folic acid refers to the oxidized synthetic compound used in dietary supplements and food fortification, whereas folate refers to the various tetrahydrofolate derivatives naturally found in food. The form of folate that can enter the main folate metabolic cycle is tetrahydrofolate (THF). Unlike natural folates, which are metabolized to THF in the mucosa of the small intestine, folic acid undergoes initial reduction and methylation in the liver, where conversion to the THF form requires dihydrofolate reductase. The low activity of this enzyme in the human liver, combined with a high intake of folic acid, may result in unnatural levels of unmetabolized folic acid entering the systemic circulation. Risks associated with excessive folic acid intake. One of the major risks associated with excessive intake of folic acid is the development of cancer. In patients with ischemic heart disease in Norway, where there is no folic acid fortification of foods, treatment with folic acid plus vitamin B12 was associated with increased cancer outcomes and all-cause mortality. In the United States, Canada, and Chile, the institution of a folic acid supplementation program was associated with an increased prevalence of colon cancer. A randomized control trial found that that daily supplementation with 1 mg of folic acid was associated with an increased risk of prostate cancer. A high intake of folic acid might mask detection of vitamin B12 deficiency and lead to a deterioration of central nervous system function in the elderly. L-methylfolate or 6(S)-5-methyltetrahydrofolate [6(S)-5-MTHF], is the primary biologically active diastereoisomer of folate and the primary form of folate in circulation. It is also the form which is transported across membranes into peripheral tissues, particularly across the blood brain barrier. Folic acid, the synthetic form of folate, must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active. Genetic mutations of MTHFR result in a cell’s inability to convert folic acid to 6(S)-5-MTHF. I got rid of Folic Acid on sale in Pharmacy, and I'm using L-Methylfolate. Be sure you buy L-Methylfolate, don't use Folic Acid, Plain Methylfolate (mixture 50% L-Methylfolate and 50% D-Methylfolate) and don't buy D-Methylfolate.

If you have MTHFR or a similar genetic polymorphism, this supplement is a lifesaver! I feel more energy, focus, better mood, sleep... just overall, better functioning. It starts to work very fast, but I believe the benefits accumulate over a few weeks.

Perfect