---
product_id: 2494120
title: "THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg"
brand: "thorne"
price: "€ 32.11"
currency: EUR
in_stock: true
reviews_count: 8
category: "Thorne"
url: https://www.desertcart.ie/products/2494120-thorne-5-mthf-methylfolate-active-b9-folate-supplement-supports-cardiovascular
store_origin: IE
region: Ireland
---

# 60 easy-to-take capsules 4 rounds purity testing 1mg bioactive methylfolate THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg

**Brand:** thorne
**Price:** € 32.11
**Availability:** ✅ In Stock

## Summary

> 🧬 Elevate your wellness game with the active folate that professionals trust!

## Quick Answers

- **What is this?** THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg by thorne
- **How much does it cost?** € 32.11 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.ie](https://www.desertcart.ie/products/2494120-thorne-5-mthf-methylfolate-active-b9-folate-supplement-supports-cardiovascular)

## Best For

- thorne enthusiasts

## Why This Product

- Trusted thorne brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Clean & Convenient:** No fillers, gluten, or artificial additives in a compact capsule designed for your busy lifestyle.
- • **Trusted by Champions:** Join the elite—endorsed by 100+ pro sports teams and top healthcare practitioners worldwide.
- • **Clinically Tested Purity:** Experience confidence with 4 rigorous lab tests ensuring unmatched product purity and potency every batch.
- • **Neuro & Cardiovascular Boost:** Support brain neurotransmitters, nerve function, and heart health with a scientifically backed B9 formula.
- • **Precision Methylation Support:** Unlock your body's full potential with 1mg of active 5-MTHF, bypassing genetic roadblocks for superior folate absorption.

## Overview

Thorne's 5-MTHF delivers 1mg of bioactive methylfolate per serving, supporting methylation, cardiovascular health, fetal development, and nerve function. Backed by 4 rounds of rigorous testing and trusted by elite athletes and healthcare providers, this clean, high-purity supplement offers superior bioavailability for those with MTHFR mutations or anyone seeking advanced B9 support.

## Description

Buy THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg on desertcart.com ✓ FREE SHIPPING on qualified orders

Review: Excellent Bioavailability with Noticeable Health Benefits - I started taking Thorne 5-MTHF after genetic testing revealed I have MTHFR mutations that affect my body's ability to process regular folic acid. My functional medicine doctor specifically recommended this Thorne product for its superior quality and bioavailable form of folate, and I've been consistently impressed with both the product quality and the health improvements I've experienced. What sets this supplement apart is the methylated form of folate, which bypasses the genetic conversion issues that affect many people. Within a few weeks of starting this supplement, I noticed improvements in my energy levels and overall sense of well-being that I hadn't experienced with regular B-vitamin complexes. My follow-up lab work showed significant improvement in my homocysteine levels, which was exactly what my doctor was hoping to achieve. The quality control and purity that Thorne is known for is evident in this product. The capsules are clean with no unnecessary fillers or artificial ingredients, and I've experienced no digestive upset or side effects. The dosing is appropriate and easy to incorporate into my daily supplement routine. The cardiovascular and neurological support benefits align perfectly with what my healthcare provider explained about methylfolate's role in cellular function. I feel confident knowing this is supporting my body's methylation processes that are crucial for so many aspects of health. The packaging protects the supplements well, and the expiration dates are always well into the future, indicating proper storage and handling. Highly recommend for anyone needing bioavailable folate, especially those with MTHFR mutations - excellent quality from a trusted brand that healthcare providers consistently recommend.
Review: High-Quality Active Folate That Makes a Noticeable Difference - I've been taking these for several months now, primarily because I have the MTHFR gene variation that makes it hard to process regular folic acid. Pros: -Bioavailability: Unlike synthetic folic acid, this is already in the methylated form, so my body can use it directly. I've noticed improved energy levels, better mood stability, and less of the "foggy" feeling I used to live with. -Purity & Quality: Thorne is known for third-party testing and minimal fillers, just cellulose capsule and the active ingredients. No gluten, dairy, or unnecessary additives. Perfect for people with sensitivities. -Supports Key Areas: It's great for methylation support, homocysteine regulation, nerve health, and overall cardiovascular wellness. -Easy to Take: Super small capsules, 60 per bottle (2-month supply at 1 per day), no taste or aftertaste. Cons (very minor): It's premium-priced compared to generic folic acid supplements, but you get what you pay for in terms of purity and effectiveness. If you're new to methylfolate, start slow, some people experience mild overstimulation at first (I didn't, but it's common advice). This has become a non-negotiable in my daily stack. If you need active B9 folate, Thorne's 5-MTHF is top-tier. Highly recommend! ⭐⭐⭐⭐⭐

## Features

- Healthy Methylation: Provides essential nutritional support in the form of bioactive, methylated folate (vitamin B9) to support the body's methylation cycle*
- Cognitive Support: Enhances the production of key neurotransmitters like serotonin, melatonin, dopamine, and other natural brain chemicals that regulate brain function and mood*
- Nerves & Circulation: Supports healthy blood vessel and nerve function, and supports healthy fetal brain development during pregnancy*
- 4 Rounds of Testing: Our state-of-the-art laboratories enable us to conduct 4 rounds of testing on every product, from analyzing the purity of raw materials to confirming the shelf life of finished formulas
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00FY8IQ7C |
| Age Range Description | Adult |
| Allergen Information | Dairy Free, Fish Free, Shellfish Free, Soy Free |
| Best Sellers Rank | #2,121 in Health & Household ( See Top 100 in Health & Household ) #2 in Vitamin B9 (Folic Acid) Supplements |
| Brand | THORNE |
| Brand Name | THORNE |
| Container Type | Bottle |
| Customer Reviews | 4.7 out of 5 stars 3,825 Reviews |
| Diet Type | Gluten Free |
| Dosage Form | Capsule |
| Flavor | Unflavored |
| Global Trade Identification Number | 00693749129011 |
| Item Dimensions | 1.7 x 1.7 x 2.97 inches |
| Item Form | Capsule |
| Item Weight | 1 Milligrams |
| Manufacturer | Thorne Research |
| Model Name | Thorne 5-MTHF 1mg - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules |
| Number of Items | 1 |
| Primary Supplement Type | Vitamin-b |
| Product Benefits | Cardiovascular Health,Cardiovascular Support |
| Specific Uses For Product | Nerve |
| UPC | 693749129011 |
| Unit Count | 60 Count |

## Product Details

- **Brand:** THORNE
- **Diet Type:** Gluten Free
- **Flavor:** Unflavored
- **Item Form:** Capsule
- **Primary Supplement Type:** Vitamin-b

## Images

![THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg - Image 1](https://m.media-amazon.com/images/I/71wLckVqoTL.jpg)
![THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg - Image 2](https://m.media-amazon.com/images/I/71lK+lmzWZL.jpg)
![THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg - Image 3](https://m.media-amazon.com/images/I/71IzTOU5zcL.jpg)
![THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg - Image 4](https://m.media-amazon.com/images/I/71LlArVcgkL.jpg)
![THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation & Homocysteine Levels* - 60 Servings - 5-MTHF 1mg - Image 5](https://m.media-amazon.com/images/I/81+btPWN+sL.jpg)

## Questions & Answers

**Q: What's the difference between this product and just a plain folate product?**
A: This product is methylated. That means that those individuals who have the genetic defect MTHFR will be able to use the folate and other B vitamins. These will be absorbed into their systems to keep homocysteine levels low among other benefits. If you don't have that defect, you do not need the methylation. Some of us will use it as long as we live.

**Q: Hi,  Can't purchase without viewing the Ingredient Label.  Could you post an image? Thank You.**
A: Hello MariaThorne Research 5-MTHF , on one capsule contains:Folate (as L-5-Methyltetrahydrofolate*) 1 mg.Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.  Until we can upload it on the list, here is a capture of it: http://ecx.images-amazon.com/images/I/81uj6EAFjZL._SL1500_.jpg The Febstore Team

**Q: What is the difference, if any, between Methyltetrahydrofolate and Methylfolate?**
A: The 5-MTHF, also known as L-methyl folate, methyltetrahydrofolate The brand is ExtraFolate-S, by Gnosis.
•        It’s the active form of folate and only the active L (aka S) form (not a racemic mixture of R and S)
•        Stabilized by calcium
•        The extraction process separates the active (S, aka L) isomer without using a solvent
•        Created by Gnosis, the technology leader in active folate supplementation
•        Contains only the L isomer (the active isomer) of 5-MTHF

Thorne's other formulas, such as the Methyl-Guard use a different form, it is still 5- MTHF, methyl folate, methyltetrahydrofolate but the brand is Quatrefolic, also provided by Gnosis. 
•        It’s the active form of folate and only the active L (aka S) form (not a racemic mixture of R and S)
•        Stabilized by glucosamine (not derived from shellfish).
•        This form passes the gastric barrier and is absorbed mainly in the small intestine by a carrier-mediated mechanism, which ensures higher folate uptake 
•        Created by Gnosis, the technology leader in active folate supplementation
•        Contains only the active L-isomer form of 5-MTHF
The difference is that one is a calcium salt and the other is a glucosamine salt. Overall, both are highly absorbable and providing 5-MTHF.

**Q: Newest bottles (November 2014) are smaller as are the capsules, much smaller. The product info looks the same. Is this the same stuff?**
A: Yes

## Customer Reviews

### ⭐⭐⭐⭐⭐ Excellent Bioavailability with Noticeable Health Benefits
*by A***S on November 27, 2025*

I started taking Thorne 5-MTHF after genetic testing revealed I have MTHFR mutations that affect my body's ability to process regular folic acid. My functional medicine doctor specifically recommended this Thorne product for its superior quality and bioavailable form of folate, and I've been consistently impressed with both the product quality and the health improvements I've experienced. What sets this supplement apart is the methylated form of folate, which bypasses the genetic conversion issues that affect many people. Within a few weeks of starting this supplement, I noticed improvements in my energy levels and overall sense of well-being that I hadn't experienced with regular B-vitamin complexes. My follow-up lab work showed significant improvement in my homocysteine levels, which was exactly what my doctor was hoping to achieve. The quality control and purity that Thorne is known for is evident in this product. The capsules are clean with no unnecessary fillers or artificial ingredients, and I've experienced no digestive upset or side effects. The dosing is appropriate and easy to incorporate into my daily supplement routine. The cardiovascular and neurological support benefits align perfectly with what my healthcare provider explained about methylfolate's role in cellular function. I feel confident knowing this is supporting my body's methylation processes that are crucial for so many aspects of health. The packaging protects the supplements well, and the expiration dates are always well into the future, indicating proper storage and handling. Highly recommend for anyone needing bioavailable folate, especially those with MTHFR mutations - excellent quality from a trusted brand that healthcare providers consistently recommend.

### ⭐⭐⭐⭐⭐ High-Quality Active Folate That Makes a Noticeable Difference
*by C***A on December 30, 2025*

I've been taking these for several months now, primarily because I have the MTHFR gene variation that makes it hard to process regular folic acid. Pros: -Bioavailability: Unlike synthetic folic acid, this is already in the methylated form, so my body can use it directly. I've noticed improved energy levels, better mood stability, and less of the "foggy" feeling I used to live with. -Purity & Quality: Thorne is known for third-party testing and minimal fillers, just cellulose capsule and the active ingredients. No gluten, dairy, or unnecessary additives. Perfect for people with sensitivities. -Supports Key Areas: It's great for methylation support, homocysteine regulation, nerve health, and overall cardiovascular wellness. -Easy to Take: Super small capsules, 60 per bottle (2-month supply at 1 per day), no taste or aftertaste. Cons (very minor): It's premium-priced compared to generic folic acid supplements, but you get what you pay for in terms of purity and effectiveness. If you're new to methylfolate, start slow, some people experience mild overstimulation at first (I didn't, but it's common advice). This has become a non-negotiable in my daily stack. If you need active B9 folate, Thorne's 5-MTHF is top-tier. Highly recommend! ⭐⭐⭐⭐⭐

### ⭐⭐⭐⭐⭐ Amazing little super pill
*by M***R on November 1, 2019*

My 12 year old son is on the autism spectrum and has eosinophilic esophagitis (EoE). He takes several medications to manage the symptoms of his autism and has a very limited diet due to his EoE. While he doesn’t necessarily have a diagnosis of anxiety or ADHD, his autism presents those symptoms due to issues with the executive functioning in his brain. His poor diet leaves him with low folate levels and low iron as well which on top of making him feel crummy sometimes, impacts his mood and mental state. Our neuropsychiatrist did a cheek swab DNA test on my son to assess how he metabolizes medications as well as identify genetic indicators to help us narrow down which medications will work best for him. We found that he poorly processes folate which in turn means he doesn’t absorb as much of his medications as he should. He already struggles with getting enough folate in his diet and to not absorb it properly only makes matters worse. She recommended we augment his diet/medications with an L- methylfolate supplement. It would in theory increase the effectiveness of his medications and ultimately reduce the dosage levels of his medications as it allows his body to better absorb the medications as well as improve his overall health. Originally we attempted to get this as a prescription but due to the nature of our prescription insurance they only allowed us to obtain it via mail. The doctor ordered twice and it never showed. For over a year my son took his medications without the supplement and we were always having to tweak the dosage or timing as he just wasn’t getting the duration of “coverage” from the meds as he should. Over the summer, we usually like to take a break from a lot of his medications (like ADHD meds). I remembered we were wanting to try this supplement and I know this type of supplement normally helps with energy, focus and mood. I ordered it at the beginning of summer and as we weaned my son off all but one medication, he remained stable and had little to no change in his disposition or functionality thanks to this pill. He takes one in the morning daily and he reports it helps him feel focused, less anxious or irritable, he is in a good mood, and isn’t groggy or feel fuzzy like some of his prescriptions make him feel. When he started 6th grade this past August, we decided to not put him on ADHD meds to help him focus on school because he was doing so well without it. We reduced the dosage of his anxiety meds and haven’t had to increase his mood stabilizer and kept it on the lowest dose to help with his anxiety and impulsivity which usually looks like ADHD in a school setting. Despite moving up to middle school with an increased course load and difficulty in material, he’s doing better this year than he ever has. He has high functioning autism and has a high IQ but has always struggled with focus and staying on task as he easily gets bored or distracted. Supplementing his medications with this is without a doubt a game changer. There are days where we have forgotten to give it to him and it isn’t super obvious but something is definitely off. It makes a difference; it fine tunes and increases the benefits we see from his medications. It also seems to help his overall health and he’s finally grown taller and gained weight thanks to being able to better absorb nutrients from his diet which has always been a struggle. It has worth every penny paying out of pocket for this supplement. It helps that Amazon has a discount when you subscribe and I qualify for the 15% discount which makes a difference. I highly recommend this for anyone whose doctor has advised they supplement their diet with L-methyfolate.

## Frequently Bought Together

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*Product available on Desertcart Ireland*
*Store origin: IE*
*Last updated: 2026-02-20*