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🦷 Elevate your smile game — enamel care that’s scientifically unstoppable!
Regenerate Enamel Science Advanced Toothpaste harnesses exclusive NR-5 technology to rebuild 82% of tooth enamel mineral within 3 days. Its clinically proven formula combines Calcium Silicate and Sodium Phosphate to restore enamel micro-hardness, combat early erosion, and remove surface stains. With a refreshing mint flavor and unisex design, it’s the essential daily toothpaste for professionals who demand both science-backed protection and fresh breath.







| Customer Reviews | 4.4 4.4 out of 5 stars (829) |
R**G
Great -- But Don't Expect a Miracle
This toothpaste is based on qualified research conducted in China in "regrowing" the crystalline structure of enamel (the hardest non-regenerative substance in the body). The problem with enamel is that it is composed of calcium phosphate in a complex structure called hydroxyapatite. This matrix does not "regrow" naturally -- so this toothpaste promotes the formation of hydroxyapatite, but only in micrometer(s) per day. The difficulty is that normal wear on the teeth is also measured in micrometers per day (ergo, don't expect a miracle). The final take-away is that this toothpaste is best used to maintain a healthy level of enamel (particularly for acidic diets) and to repair non-contact dental surfaces. No, it will not fix cavities but might help with micro-pitting. For me, it seemed to restore some of the minor enamel loss I had experienced on the edge of my upper incisors. I consider this to be part of good dental hygiene regimen along with flossing and regular dental care.
1**D
Unbelievable
I was reading the good and the bad reviews on this product and didn’t know what to believe. I was looking for something to get my teeth back to looking beautiful strong and healthy again. Not just a cover up paste but a paste that will actually rebuild my teeth strength and color. It’s hard to believe but right after the first use of the toothpaste I noticed progress. I wish I took a before and after pic but I didn’t because I expected disappointment lol. All I know is this toothpaste is legit amazing and I’m definitely sticking to this. There’s no irritations at all and the flavor is decent not too strong it doesn’t annoy u. I highly recommend this to everyone. It helps if ur teeth r transparent as well. I’ve only had it for a few days now and I can’t wait to update u guys in a month or so! I’m not big on writing reviews and I’m not big on believing a lot of “miracle” pastes but this is definitely something. Give it a try!
G**P
Doctor recommended
When I skip a day, I notice the difference. It doesn't have a strong minty taste and my mouth feels dry after using it. It's expensive compared to the brands I used to buy, but cheaper than false teeth and has helped with the sensitivity and pain. It's not a permanent fix, it's a constant thing. I'll keep using it until there's something better.
A**R
Try it
My dentist just gave me the best review I’ve had in 5 years all thanks to this product . I’ve been using it since April 2025. I had no cavities and almost no tartar or weak spots this time . I had a weak spot filling in April & found this product right afterwards & gave it a try .
P**5
A life saver but overpriced
I was desperately seeking a remedy for the back of my front teeth feeling weak and not having dental insurance to go in for bonding. The body cannot regenerate enamel once it is gone, however found this brand owned by unilever and gave it a go. I had used common toothpaste for sensitive teeth and repair found at the local drugstores, however I believe they just numb the teeth so one does not feel the weakness in the teeth. What a difference it has made. Ordered multiple tubes and using it almost for one month now, and there has been a drastic improvement in the look and feel of my teeth. I felt a difference as soon as I used it. I did not even buy the serum, and I imagine that would work even better. They look whiter, stronger, healthier. Feels so much better. However the price seems to keep going up. I am switching to another product for the time being which is not as expensive and from a different country. Maybe that one works even better. You've lost a satisfied customer by charging nearly $30 for a tube of toothpaste, doubling the price in a matter of weeks. Disappointed, but a lovely product.
A**N
"jury still out"
I have been using this for about 4-5 months now. The "jury" is still out. more or less. I hoped that that my dentist would be able to view/inspect my teeth and provide some kind of measure.(she had commented that my enamel was eroding much earlier in 2018)which is why I got the product . now I have not told her that I am using this product as dentists are "biased" to a large extent on what is taught to them in dental school. and additionally this product obviously is not manufactured in the USA. I will wait for more dental appointment to happen and see what my dentist says then its also important to know that (Unilever who makes this product)doesn't provide instructions in English on the actual product. you will need to search on Youtube for videos that do provide instruction for using/applying the '"serum".the vidoes ARE NOT provided by Unilever, but rather by individuals who do use the product. its not hard use the serum but the videos do provide important details to using the serum
J**Y
WONDERFUL PRODUCT!
Best toothpaste in the world
A**R
Excellent
I bought this for my elderly father. He had been complaining for months about teeth sensitivity and pain, to the point that he wasn’t eating well anymore and lost some weight. The procedure the dentist recommended wasn’t appealing to him and he had mentioned to me that he had stopped brushing his teeth altogether. Soft bristle toothbrushes didn’t help. I ultimately bought this for him to try and he reluctantly did. He said that the first night he used it, he was able to sleep soundly without any aching pain stemming from teeth sensitivity. Who would have thought that something so trivial as toothpaste could improve someone’s quality of life… this product does what it says and I would definitely buy it again! I don’t know if his teeth sensitivity will return if he stops using it but in the meantime this is my solution. If they sold multi packs, I would buy a boat load!
Trustpilot
1 month ago
1 month ago