

Desertcart purchases this item on your behalf and handles shipping, customs, and support to Ireland.
✨ Clear skin, clear mind — own your glow with Differin! 💼
Differin Acne Retinoid Treatment Gel features 0.1% adapalene, the first FDA-approved OTC retinoid acne treatment in over 30 years. This dermatologist-recommended, oil-free gel penetrates deep into pores within 5 minutes to clear, treat, and prevent acne, reducing breakouts by up to 87% in 12 weeks. Its gentle, fragrance-free formula is ideal for sensitive skin and daily use, making it the go-to solution for professionals seeking effective, prescription-strength acne care without the hassle of a prescription.















| ASIN | B07ZTN5N1V |
| Active Ingredients | Adapalene 0.1% |
| Best Sellers Rank | #32 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #1 in Facial Skin Care Sets & Kits |
| Brand | Differin |
| Brand Name | Differin |
| Container Type | Bottle |
| Customer Reviews | 4.6 out of 5 stars 19,337 Reviews |
| Global Trade Identification Number | 00302994910403 |
| Item Form | Gel |
| Item Highlight | 90-Day Supply Pump, Over-The-Counter Retinoid, Clears Breakouts, Gentle For Sensitive Skin, Dermatologist Recommended |
| Item Type Name | Retinoid |
| Item Weight | 45 g |
| Manufacturer | Galderma |
| Manufacturer Part Number | 0299.491040 |
| Material Features | Fragrance Free, Non-Comedogenic |
| Model Number | 0299.491040 |
| Number of Items | 1 |
| Package Size Name | 90 Day Supply |
| Product Benefits | Anti-Acne |
| Scent | Unscented |
| Scent Name | Unscented |
| Set Name | Style/Size Set |
| Size | 1.6 Ounce (Pack of 1) |
| Skin Type | Acne-Prone, Combination, Normal |
| Special Ingredients | Retinoid |
| Target Use Body Part | Face |
| UPC | 302994910403 |
| Unit Count | 1.6 Ounce |
S**N
Worth the patience - actually works!
This is officially my second purchase, and I can confidently say it’s earned a permanent spot in my routine. It definitely doesn't work overnight, so you have to be patient with it. However, with consistent daily usage, I started noticing a real difference in my skin texture and overall clarity. It significantly minimized the stubborn acne marks left behind by my closed comedones. If you're willing to stick with it through the initial adjustment phase, the long-term results are completely worth it!
A**R
Highly Effective, Gentle, and Worth It for Acne-Prone Skin
This acne treatment gel is one of the best skincare products I've used. It’s powerful yet gentle, and it really delivers on clearing breakouts and preventing new ones. 🔹 Clears Acne & Helps Prevent New Breakouts It works deep into pores to target acne at the source — rather than just drying out existing pimples, it helps stop new ones from forming. After a few weeks of use, I noticed fewer breakouts and smoother skin overall. 🔹 Gentle Enough for Sensitive Skin Even though it’s a retinoid and highly effective, the formula is water-based, oil-free, and non-comedogenic. It didn’t irritate my skin or cause excessive dryness — you get the power of a prescription-strength product with a surprisingly gentle finish. 🔹 Improves Skin Texture and Reduces Acne Marks Over time, my skin tone looked more even, and old blemishes faded faster. It not only treats active acne but also helps with discoloration and overall smoothness. 🔹 Easy Daily Use & Real Results It integrates easily into a nightly skincare routine. Once applied, it absorbs quickly and layers well under moisturizer. Within a few weeks, skin felt clearer and healthier — you can actually see the difference on breakouts, tone, and texture. ✅ Pros: Powerful acne treatment that works deep in pores Helps prevent future breakouts instead of just treating existing ones Gentle enough for sensitive/acne-prone skin Improves skin texture and marks over time Easy to use daily and delivers real results ❌ Cons (minor): Skin may feel slightly dry at first — best to pair with a good moisturizer Overall: If you struggle with acne or frequent breakouts, this gel is a game-changer. Effective, gentle, and noticeable results — a solid 5-star product that I’d recommend without hesitation.
J**.
Works well
Have had a nasty ongoing cyst behind my ear that was the size of a hazelnut, fpr months! I drained it a few x with sterile needles and such (pls don't do that) but always came back. I started applying this on it once a day. After 4 days, it drained on it's own. After cleaning it well, i applied a bandaid for 1 day, then resumed this product. Area is now completely dried out and flat. Just a few days away from being 100% resolved. I also apply it to hormonal acne as spot treatment and works pretty fast. Only place i really did get pretty dry was my chin area but with face oil, it was manageable.
E**A
My skin feels dry
I’ve been using Differin gel to help with breakouts, and it has noticeably improved my skin over time. It works well, but it can make my skin feel dry, so I recommend using a good moisturizer along with it.
L**I
to acne treatment for years
My go-to acne treatment for years I’ve been using this Differin acne treatment for more than three years, and it has become one of my go-to products for managing breakouts. I mainly use it at night and apply a small amount to areas where I’m experiencing breakouts. Over time, I’ve been very happy with how it helps keep my skin clearer and manage occasional acne. A little goes a long way, so one tube lasts quite a while when used as directed. I would recommend starting slowly if you’re new to retinoids, since they can cause dryness or irritation while your skin adjusts. I also avoid applying it too close to my eyes and other sensitive areas. After using it consistently for more than three years, I can honestly say this is one acne treatment I keep coming back to. It has worked well for me and is definitely worth considering if you’re looking for an acne treatment.
I**L
Effective against goosebumps(hyperkeratosis)
This is a magical gel; over time, it helped me get rid of the "goosebumps" texture on my face—something I had been trying to eliminate for years! I highly recommend it. It doesn't work instantly, so be patient and wait for the results.
D**O
Great best out there.
This is such a help. You will go thru skin purging. I use in evening with my acne wash in evening. After 8 weeks my skin and pores clear, smoothe skin. I skin am having minor breakouts because it can take up to six months for skin purging and cysts acne to clear. Im very happy. Do not expect immediate results. It takes time. Works immediately. My pores and cysts responded fay after using ..
S**O
Worth Stocking Up On
Every time I'm in the US, I make sure to pick up Differin. It's much harder to get abroad, as in many other countries, you either need a prescription for adapalene or it simply isn't sold at all. As long as your skin tolerates adapalene, I think it's a great addition to a skincare routine. This is my first time buying the pump version. I'd only used the original tube before, and while it was a little more travel-friendly, the tube would eventually crack. Because the product lasts such a long time, once that happened, it would get messy, and I'd end up wasting some of it, which was always frustrating. It's not an expensive product, but it's still a shame to waste it. I guess my only concern with the new pump is whether the cap will eventually break as well. Time will tell, but so far I think it's a great improvement. This was also my first time ordering it through Amazon, and I had no issues with the packaging or delivery. Happy to have this back in my skincare routine.
J**.
Dried my skin
I used it only for 3 days and it dried my skin so much that I had red patches. Stopped using immediately
Trustpilot
4 days ago
2 weeks ago