---
product_id: 14345228
title: "Methyl-Guard Plus - Active Folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports Methylation & Healthy Level of Homocysteine* - Gluten, Dairy & Soy-Free - 30 Servings"
brand: "thorne"
price: "€ 75.48"
currency: EUR
in_stock: true
reviews_count: 12
category: "Thorne"
url: https://www.desertcart.ie/products/14345228-methyl-guard-plus-active-folate-5-mthf-with-vitamins-b2
store_origin: IE
region: Ireland
---

# Methylcobalamin B12 for optimal absorption 4 rounds of rigorous purity & potency testing 5-MTHF active folate for superior methylation Methyl-Guard Plus - Active Folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports Methylation & Healthy Level of Homocysteine* - Gluten, Dairy & Soy-Free - 30 Servings

**Brand:** thorne
**Price:** € 75.48
**Availability:** ✅ In Stock

## Summary

> 🧬 Elevate your wellness game with the methylation masterclass!

## Quick Answers

- **What is this?** Methyl-Guard Plus - Active Folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports Methylation & Healthy Level of Homocysteine* - Gluten, Dairy & Soy-Free - 30 Servings by thorne
- **How much does it cost?** € 75.48 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.ie](https://www.desertcart.ie/products/14345228-methyl-guard-plus-active-folate-5-mthf-with-vitamins-b2)

## Best For

- thorne enthusiasts

## Why This Product

- Trusted thorne brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Clean & Allergen-Free:** Gluten, dairy, and soy-free formula designed for sensitive, health-conscious professionals.
- • **Tested for Excellence:** Four rigorous rounds of lab testing guarantee purity, potency, and shelf-life stability—because your health deserves no compromises.
- • **Clinically Trusted Formula:** Endorsed by 100+ pro sports teams and top healthcare practitioners, ensuring you get a clean, reliable supplement every time.
- • **Neuro & Heart Vitality Boost:** Supports neurotransmitter production and cardiovascular health to keep your brain sharp and your heart strong.
- • **Precision Methylation Support:** Harness the power of active folate (5-MTHF) and methylcobalamin B12 to optimize your body's methylation pathways and maintain healthy homocysteine levels.

## Overview

THORNE Methyl-Guard Plus delivers active folate (5-MTHF) alongside methylcobalamin B12 and essential B vitamins to support healthy methylation and balanced homocysteine levels. Backed by four rounds of stringent testing and trusted by elite athletes and healthcare pros, this gluten, dairy, and soy-free formula promotes cardiovascular and brain health with superior bioavailability for millennial professionals seeking peak performance and longevity.

## Description

Buy THORNE - Methyl-Guard Plus - Active Folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports Methylation & Healthy Level of Homocysteine* - Gluten, Dairy & Soy-Free - 30 Servings on desertcart.com ✓ FREE SHIPPING on qualified orders

Review: MTHFR - High quality B complex! Helpful for MTHFR gene mutation. I have been using them for about six months now and notice a huge difference in my cycle regularity, as it has very high amounts of B6 and a methylated form, I’m convinced is due to this product. My menstrual cramps have all but almost completely disappeared, which is absolutely amazing considering I have struggled with that since my teens could not recommend this more, especially for women struggling with similar issues.
Review: Love! - Love! It’s high quality, easy to take, and has really helped lower my homocysteine levels as recommended by my doctor. I appreciate that it uses active forms of B vitamins like 5-MTHF for better absorption. Thorne is such a trusted, clean brand, which gives me extra confidence in what I’m taking. I feel more balanced and energized since adding it to my routine—definitely a product I’ll keep using!

## Features

- Healthy Methylation: Provides B vitamins and other nutrients that optimize methylation and promote a healthy level of homocysteine in the bloodsteam*
- Active Forms: Formulated with superior methyl donors, including betaine and active folate (5-MTHF) and B12 (as methylcobalamin), to optimize utilization in the body
- Heart and Brain Benefits: Sustains cardiovascular health and promotes healthy brain function by supporting neurotransmitter production and enhancing cellular energy levels*
- 4 Rounds of Testing: Our state-of-the-art laboratories enable us to conduct 4 rounds of testing on every product, from analyzing the purity of raw materials to confirming the shelf life of finished formulas
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B00O5AHC4S |
| Best Sellers Rank | #5,345 in Health & Household ( See Top 100 in Health & Household ) #98 in Blended Vitamin & Mineral Supplements #537 in Diet & Sports Nutrition |
| Customer Reviews | 4.6 4.6 out of 5 stars (1,700) |
| Date First Available  | March 8, 2011 |
| Department  | All Ages |
| Is Discontinued By Manufacturer  | No |
| Item model number  | No Model |
| Manufacturer  | Thorne Research |
| Product Dimensions  | 2.38 x 2.38 x 4.23 inches; 3.84 ounces |

## Product Details

- **Brand:** THORNE
- **Diet Type:** Gluten Free
- **Flavor:** Unflavored
- **Item Form:** Capsule
- **Primary Supplement Type:** B-Complex

## Images

![Methyl-Guard Plus - Active Folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports Methylation & Healthy Level of Homocysteine* - Gluten, Dairy & Soy-Free - 30 Servings - Image 1](https://m.media-amazon.com/images/I/61BtsSBpN9L.jpg)

## Questions & Answers

**Q: What is the difference between "methyl-guard" and "methyl-guard plus" products?**
A: Methyl Guard plus is stronger.  The Methyl Guard Plus contains about twice as much b12 (3mg vs 1.2mg), about twice as much folate (3mg vs 1.2mg), about twice as much b6 (45mg vs 20.4mg) and contains Riboflavin.

**Q: Why doesn't it show the label, I'm not going to pay this amount for something without knowing what and how much is in it!**
A: If you look at the selection of pictures to right of the bottle the bottom picture includes the label.  You can click on that image to show it larger.

**Q: are these capsules enteric coated? taking pyridoxal-5-phosphate without enteric coating useless**
A: Not coated. Just a vegetarian capsule. For me, my body has been starved of these active forms of B vitamins that it's anything but useless. If you want to encourage it not to digest as quickly, a trick my doctor tells me to do (with fish oil for example) is to freeze the capsule so that it takes longer to digest. You can look for the specific forms of active B vitamins to find them enteric coated. Details on the product: https://www.thorne.com/products/dp/methyl-guard-plus-reg

**Q: Does this turn your stools orange colored?**
A: Orange stools may signify you are dumping copper. Look up un bound copper, bioavailable copper and copper toxicity. You need boron and vit K2.

## Customer Reviews

### ⭐⭐⭐⭐⭐ MTHFR
*by J***N on October 12, 2025*

High quality B complex! Helpful for MTHFR gene mutation. I have been using them for about six months now and notice a huge difference in my cycle regularity, as it has very high amounts of B6 and a methylated form, I’m convinced is due to this product. My menstrual cramps have all but almost completely disappeared, which is absolutely amazing considering I have struggled with that since my teens could not recommend this more, especially for women struggling with similar issues.

### ⭐⭐⭐⭐⭐ Love!
*by A***N on September 22, 2025*

Love! It’s high quality, easy to take, and has really helped lower my homocysteine levels as recommended by my doctor. I appreciate that it uses active forms of B vitamins like 5-MTHF for better absorption. Thorne is such a trusted, clean brand, which gives me extra confidence in what I’m taking. I feel more balanced and energized since adding it to my routine—definitely a product I’ll keep using!

### ⭐⭐⭐⭐⭐ Dr recommended.
*by G***D on September 16, 2025*

Dr recommended for my MTHFR gene mutation. No odor, not taste, no after taste. No stomach issues. Hope to see the benefit in raising my folate and lowering my homocysteine and thereby lowering a risk of heart attack. .

## Frequently Bought Together

- THORNE Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports methylation & Healthy Level of homocysteine* - Gluten, Dairy & Soy-Free - 90 Capsules
- THORNE Magnesium CitraMate - Magnesium Supplement with Citrate-Malate - Support Heart, Skeletal Muscles, Cardiac, Lung Function, and Bone Density* - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules
- THORNE Vitamin D-5000 - Vitamin D3 Supplement - Support Healthy Bones, Teeth, Muscles, Cardiovascular, and Immune Function* - NSF Certified for Sport - Dairy-Free, Soy-Free - 60 Capsules

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*Product available on Desertcart Ireland*
*Store origin: IE*
*Last updated: 2026-01-28*